What is the current scientific basis on NMN?Updated 8 months ago

Thousands of people have taken NMN in reasonable doses (usually 125 mg to 1 g) over the years without problems, and its safety has been confirmed by more than scientific studies.

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  • The efficacy and safety of nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial (2023): Walking distance increase during the six-minute walking test was statistically significantly higher in the 300 mg, 600 mg, and 900 mg groups compared to placebo at both days 30 and 60 (all p < 0.01), with longest walking distances measured in the 600 mg and 900 mg groups. The blood biological age increased significantly in the placebo group and stayed unchanged in all NMN-treated groups at day 60, which resulted in a significant difference between the treated groups and placebo (all p < 0.05) https://pubmed.ncbi.nlm.nih.gov/36482258/
  • Safety of NMN supplementation up to 1.25 g/day with no adverse effects https://rdcu.be/c4gpB
  • Safety of NMN intake, pharmacokinetics and positive effect on blood glucose: https://www.jstage.jst.go.jp/article/endocrj/67/2/67_EJ19-0313/_pdf/-char/en
  • NAD+levels are significantly increased / safety of NMN: https://www.frontiersin.org/articles/10.3389/fnut.2022.868640/full
  • NMN increases insulin sensitivity in prediabetic women: https://pubmed.ncbi.nlm.nih.gov/33888596/
  • NAD+ increase with supplementation: https://www.frontiersin.org/articles/10.3389/fragi.2022.851698/full
  • Improved muscle strength and performance: https://www.researchsquare.com/article/rs-455083/v1
  • NMN supplementation increases blood NAD concentrations and is safe and well tolerated when taken orally up to 900 mg NMN daily / improves physical performance: https://link.springer.com/article/10.1007/s11357-022-00705-1 
  • Improves aerobic capacity in amateur runners https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00442-4 
  • Potential of NMN to prevent loss of physical capacity and improve fatigue in older adults https://www.mdpi.com/2072-6643/14/4/755
  • Meta-analysis - NAD+ precursors has a significant positive effect on patients with cardiovascular disease and dyslipidaemia https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-022-00653-9 
  • Castro-Marrero J, Sáez-Francàs N, Segundo MJ, Calvo N, Faro M, Aliste L, Fernández de Sevilla T, Alegre J. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial. Clin Nutr. 2016 Aug;35(4):826-34. doi: 10.1016/j.clnu.2015.07.010. Epub 2015 Jul 17. PMID: 26212172.
  • Pulse wave velocity values indicating arterial stiffness tended to decrease in the NMN intake group. However, no significant difference was found between the two groups. Long-term NMN supplementation at 250 mg/day was well tolerated and did not cause adverse events. NMN safely and effectively elevated NAD+ metabolism in healthy middle-aged adults. https://pubmed.ncbi.nlm.nih.gov/36797393/ 
  • Towards personalized nicotinamide mononucleotide (NMN) supplementation: nicotinamide adenine dinucleotide (NAD) concentration (not yet peer-reviewed / pre-print) https://www.medrxiv.org/content/10.1101/2024.02.19.24303025v1