Avea
Avea
All articles

What is the scientific background of the Stabiliser?Updated 8 months ago

Our products are based on studies covering the individual ingredients. Each of the 3 selected ingredients in our Stabiliser have substantial clinical evidence showing positive effects on blood glucose and insulin levels.

Here is a more detailed explanation of how the Stabiliser works:
The main ingredient Reducose blocks carbs/sugar absorption by an average of 40% to balance blood sugar and helps getting off the blood sugar rollercoaster. The benefits of a flatter blood sugar curve include a slowing of the ageing process (less glycation), better heart and brain health, better skin, less inflammation and a lower risk of metabolic disease. To name just a few.
It’s primary action driven by the 250 mg white mulberry extract (Reducose®)is actually to block the enzyme (Alpha-glucosidase) which breaks down carbs & disaccharides (sugars) into glucose. This is because the active molecule in the natural white mulberry extract we use has a very similar shape to glucose and is able to bind to the receptors of that enzyme for about 1 hour.

On white mulberry extract you can find over 600 scientific papers with different levels of evidence. We‘re focusing on gold standard clinical trials and other in-vivo experimental studies as well as on meta-analysis and systematic reviews which have the highest evidence level. According to a meta-analysis from April 2022 it provides evidence that Morus alba (white mulberry extract) can help balance blood sugar levels. Another very recent human trial underlines that mulberry-extract improves glucose tolerance and decreases insulin concentrations in healthy adults.  https://pubmed.ncbi.nlm.nih.gov/28225835/

Not all Alpha-glucosidase will be blocked but clinical research reveals a 40% reduction in carb absorption on average and associated blood glucose levels after a carb-rich meal; meaning the peak of blood glucose after a meal is much lower and consequently no sugar crash is experienced.

The 40% undigested carbs/sugars are not absorbed by the intestine but still have 2 beneficial effects.
1. Increasing the sensation of satiety by activating the Ileal break, an intestinal feedback mechanism that is triggered by nutrients at a specific location in the intestine.
2. act as a prebiotic to our microbiome (food for our good bacterias), which in turn forms small chain fatty acids (butyrate). Released butyrate from the large intestine is taking up and ketones are created as an alternative energy source.

The other ingredients: 250 mg Berberine (natural source) lowers fasting blood glucose and has anti-inflammatory properties. Furthermore, it has cholesterol-binding properties & supports lower fasting sugar level. 100 mg Chromium Picolinate (from yeast fermentation process) can improve insulin sensitivity and is involved in glucose metabolism. All ingredients in our Stabiliser are safe and cause none of the side effects which can happen with other carb blockers (no bloating or intestinal discomfort).

Here the selected scientific references to Berberine and Chromium Picolinate:

  1. Birdsall T, Kelly G. Berberine: therapeutic potential of an alkaloid found in several medicinal plants. Alt Med Rev. 1997;2(2):94-103.
  2. Lee YS, Kim WS, Kim KH, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes. 2006;55(8):2256-2264.
  3. Xu Z, Feng W, Shen Q, Yu N, Yu K, Wang S, Chen Z, Shioda S, Guo Y. Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation. Aging Dis. 2017 Dec 1;8(6):760-777. doi: 10.14336/AD.2016.0620. PMID: 29344415; PMCID: PMC5758350.
  4. Anton SD, Morrison CD, Cefalu WT, Martin CK, Coulon S, Geiselman P, Han H, White CL, Williamson DA. Effects of chromium picolinate on food intake and satiety. Diabetes Technol Ther. 2008 Oct;10(5):405-12. doi: 10.1089/dia.2007.0292. PMID: 18715218; PMCID: PMC2753428.
  5. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008 May;57(5):712-7. doi: 10.1016/j.metabol.2008.01.013. PMID: 18442638; PMCID: PMC2410097.
  6. Brownley, K. A., Von Holle, A., Hamer, R. M., La Via, M., & Bulik, C. M. (2013). A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and Chromium (BEACh) study. Journal of psychosomatic research, 75(1), 36–42.
  7. Pei D, Hsieh CH, Hung YJ, Li JC, Lee CH, Kuo SW. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism. 2006 Jul;55(7):923-7.


We are confident that this combination of ingredients is beneficial for many people. Nevertheless, we are currently planning a small human trial with individuals who’ll measure the effect with Continuous Glucose Monitoring sensors. Here are some example results of our pre-study phase:

These own findings confirms the effective reduction of the glucose spike - in our case by at least 60%. Much more than claimed by our supplier Phynova who produces Reducose®. Note that the Stabiliser’s effect can vary depending on the type of carbs and people’s individual glycemic response.

 

Here are a selection of scientific evidences of our product:

Related to

Was this article helpful?
Yes
No
Powered by