Why are you using capsules and not sublingual or liposomal formulations?Updated 8 months ago

Significant for bio-availability is the stability of the NMN. There are different formulations on the market, meaning different forms of making NMN available for our body (liposomal, stabilised, micronised, sublingual etc.). Currently, there is no substantial evidence supporting that liposomal NMN is superior to other forms of the compound in terms of bio-availability. It's only a hypothesis. Almost all clinical trials which backs the positive NMN effects have been made with normally stabilised NMN in capsules. Liposomal formulations often have some drawbacks: uncertainty on stability and purities. Our NMN is double-tested on purities and heavy metal impurities, stabilized and even micronized, so we're estimating an highly effective bio-availability. 

However, the way in which NMN is absorbed is the subject of intensive research. We can assume that an adequate proportion is absorbed, as an NMN-specific transporter was found in the small intestine in 2019 (Slc12a8) (1). We cannot say exactly, because it still plays a role here whether this transporter functions adequately in every human being. Since our NMN is protected by the capsule, stabilised and micronised, we assume an effective bio-availability based in scientific findings. It was found that orally administered NMN is rapidly absorbed (within 10 min.) and converted to NAD+ in peripheral organs such as liver (within 30min). (2)

250 mg NMN has already proven to be effective. i.e., this dose already shows a health-promoting and life-prolonging effect. Of course, up to 500 mg (between 30 and 60 years) and 750 mg (for a 90 kg man over 60) are possible without any problems. (2) (3)

The most recent clinical trial by Lin et al. from this September 2022 shows that a dose between 300 and 600 mg has the greatest effects on people who had not taken NMN before (NAD levels, biological age, fitness). Within the first two months, it made no significant difference whether one took 600 mg or 900 mg. (4)

(1) https://www.nature.com/articles/s42255-018-0009-4

(2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668137/

(3) https://www.researchsquare.com/article/rs-455083/v1

(4) https://link.springer.com/article/10.1007/s11357-022-00705-1